7 Khoon Maaf movie is a romantic misadventures story of an Anglo-Indian woman Susanna Anna-Marie Johannes, a beautiful lass who over the course of thirty-five odd years, gets married seven times due to the untimely and mysterious deaths of half a dozen of her hapless husbands.

The strange circumstances of their deaths, makes Susanna a prime accused. Did the husbands deserve to die? Were the murders out of necessity or pure blood-lust? Does Susanna ever find her one true love?